Ghost town of Shafter, TX
I don't want to say the road from Presidio to Marfa has only one landmark — there are a few historic markers at ranch gates, and the Chinati Mountains are close enough to the west to count off the peaks as you pass them (or signs for them) — but, there's only one obvious stop for a cyclist, Shafter.
It's an old silver mining town with the ruins of several stone buildings from an old mining operation. There are also a few currently occupied houses and a Catholic church, where we got water from a spigot another cycle tourist told me about three years prior.
Concordia Cemetery in Shafter. The display on the left is one big ad for the nearby Cibolo Creek Ranch, the resort where Antonin Scalia was vacationing when he died.
Cibolo Creek in Shafter could be a good water source even if the spigot at the church wasn't on